The Metronomicon: Slay the Dance Floor combines familiar elements from Rhythm and RPG genres. During battles, the player hit notes to the beat of the soundtrack while switching between their team of four heroes. Heroes cast spells and activate abilities by completing rhythm sequences in lanes that scroll over their heads while electronic and indie rock tracks play. Monsters appear on the right side of the screen while the music plays, new ones swapping in as others are knocked. Players must swap between tracks on-the-fly in order to heal, cast elemental damage spells and cast buffs and debuffs. Successfully hitting notes allows the player to launch attacks or defenses against different enemies throughout the songs and levels. The re-release (entitled "Slay the Dance Floor") added new playable characters, passive abilities, Endless Mode, and a cooperative option for all modes of the game.