August 1999. 90% of humanity has died due to a strange energy falling on Earth. The remaining humans have named this energy Force. To protect themselves against the Force they have remodeled their bodies and created a new generation of man.

Besides the names of several characters, the North American version, Superior Soldiers lacks other things that are seen in the Japanese version, Perfect Soldiers. The Japanese version has an announcer shouting the name of the game at the title screen, as well as names of "who VS. who" at the VS. screens in Engrish. However, the well-known "Winners Don't Use Drugs" screen and new color graphics were added to the North American version.