The main objective of Zuma's Revenge! is to clear strings of rolling balls by matching balls of the same color. The player controls a frog that shoots colored balls at the strings. The frog always points in the direction of the mouse. When three or more balls of the same color are matched together, they are cleared from the playfield. Gaps can be formed through which the player can shoot more balls or collect fruit. Gaps are automatically closed if the balls at both ends of the gaps are (or become) the same color, potentially leading to chain reactions.