Dino Crisis 2 is a Action-adventure video game. The story follows the events of the last game, where Regina is now on another mission involving a facility located close to the fictional Edward City, where a major anomaly has caused the whole island to be transported back in time to the era of the dinosaurs, along with all the human inhabitants. Regina is sent on a rescue mission with her new ally Dylan Morton, who has a strange connection to the events on the island. The player's control switches between Regina and Dylan at specific points in the game.