Against Rome is a real-time strategy game set in the peak era of the Roman Empire. Players can represent Teutons, Huns and Celts, trying to retain their independence and expand their lands across Britain, Germany, Russia, Eastern Europe and Italy. Successful play involves being aggressive, brutal and greedy, as this was the only way to made inroads into Rome's power.

The game's main campaign includes 24 missions, as well as accurate recreations of historical incidents. There are unique units, buildings, and even battle formations for each tribe. Chiefs earn glory points by fighting and can use them in a variety of ways. Weather effects and a day-night cycle influence gameplay. The game also has 8-player multiplayer support across 10 scenarios.