A follow-up to the original Math Blaster! games, Math Blaster: In Search of Spot is an educational title with arcade elements designed to help students learn maths while having fun.

The game allows students to practice basic addition, subtraction, multiplication, and division skills in addition to fractions, decimals, percents, estimation, and number patterns. The subjects can be practiced separately or together in review. Six levels of difficulty are provided. Like the previous titles, the game also includes an editor to create new problem sets (present in the PC version only).

Math Blaster's friend and assistant, Spot, is kidnapped by the evil Trash Alien at the beginning of the game. The Galactic Commander gives Math Blaster the mission to follow the Trash Alien to his home planet and rescue Spot.

The game starts with a complete mission (story mode). The mission consists of a series of four (three in the console versions) math activities (mini-games) strung together with cut-scenes. The activities can also be played separately, for practice or for score.