Tanks' Destroyer simulates a unit of legendary 45-mm anti-tank gun M-42 used by Soviet forces in World War II. During a campaign, the player should repel attacks of Nazi tanks such as Tiger, Panther, and suppress enemy firing points. Under the player's command, the gun can fire at selected enemy targets and change its position. The enemies are retaliating, causing damage to gun's personnel (pointer, loader, driver) and equipment (gun itself). Critical state of the gun is shown by cracks in the sight optics. Recharging takes time, especially if the loader is injured.

F2 switches between full screen mode and sight mode. The map can be accessed with F1.