Mystery at the Museums is the second in the Adventures with Edison series. The game is sponsored by Smithsonian Institution and allows the player to visit different museums.

A detective agency is searching for missing treasures. They've been misplaced or hidden in museums. Accompanied by Edison, a happy little fellow, the players visits the museums and must solve various puzzles. Puzzle types include: match two or three hidden pictures of a kind, slide the tiles to compose the picture, falling block puzzle, match the constellation from a selection, etc. The answers are fulfilled with additional educational information.

There are game sessions of different difficulties for childen in the age category 6-13+. Finding all the treasures in a session places the winner in the High Scores table. The looks of Edison may be adjusted. The game session progress is saved / loaded for each game profile.