Special Criminal Investigation is the sequel to the 1988 original Chase H.Q. Instead of the black Porsche 928 of the first game, the player commands a red example of the just-introduced (at the time) Nissan 300ZX Z32 T-Top Turbo. Unlike the first game, the player was able to fire at offending vehicles, with some cabinets containing buttons on the steering wheel, and others having a fire button on the gearshift, along with a button to activate the nitrous boost.

The game brings back protagonists Tony Gibson and Det. Raymond Broady of the first game, and their second game appearance. Broady has taken over the driver's seat this time, while Gibson, as the passenger, serves as the gunman.