In 2025, a militia of androids, who call themselves the "R.O.M." - "Rage Of the Machines", has suddenly materialized in Los Angeles. The androids launch a fierce offensive against the entire West Coast regions and the federal government responds by mobilizing its ace counterterrorist forces "S.I.F.A.T". Against the backdrop of the Pacific coast, a struggle of unparalleled intensity has begun. L.A. Machineguns: Rage of the Machines serves as the sequel to Gunblade NY: Special Air Assault Force.