Lakya is a technologically-advanced civilization on a planet far from our own galaxy. The planet's inhabitants have unknowingly unleashed the planet's life force, Evol. As the Evol drifts from Lakya, it reaches a planet called Cokyo, whose inhabitants use it to attack and invade Lakya. Now, fighters from Lakya must fight back against the invading army by using the Evol themselves.

Darwin 4081 is a vertical scrolling shooter based on the 1987 Data East coin-op Super Real Darwin. The main attraction of the game is the ability to evolve your ship into a wide variety of different forms, each with their own attack abilities, by collecting DNA dropped by enemies. Other powerups will increase you ship's speed, give you an option that follows your ship, or even increase the power of your smart bombs. The game features surreal futuristic art design fitting of its title.