Corpse Killer is a full-motion-video (FMV) shoot-'em up. It seems the evil genius Dr. Hellman has found a way to raise the dead and created an island of zombies. The player is an elite special forces soldier who has been parachuted onto the island, it is up to them to shoot their way through the undead hordes and stop Dr. Hellman.

The game is played from a first-person perspective. Various zombies pop up in front of a video background and the player must shoot them down either by moving a mouse cursor on screen or by using a light gun.