Puzzle Piece Panic! is a Tetris clone. Falling tetrad pieces must be arranged inside a well to form horizontal lines. When a complete line is formed, it is removed from screen. Pieces can be moved horizontally, rotated by pressing the action button (and up for opposite rotation) and accelerated by pressing down. The game has 4 possible variations:
A: pieces above the removed line collapse, the goal is to outlast, the game increases one difficulty level for each 10 lines removed,
B: pieces above the removed line collapse, the goal is to remove 25 lines, the game doesn't increase the difficulty level,
C: pieces above the removed line don't collapse, the goal is to outlast, the game increases one difficulty level for each 10 lines removed,
D: pieces above the removed line don't collapse, the goal is to remove 25 lines, the game doesn't increase the difficulty level,
The game is the first to feature polyphonic music in Odyssey²'s history, which is played every time the game is won or lost.