Mysterious forces are at work when worlds collide and the casts of eleven of the biggest Cartoon Network shows battle one another in this all-star brawler! Play as 18 of your favorite Cartoon Network characters based on your favorite show, and look out for cameos from an additional 19 characters who jump in and assist in combat!

Cartoon Network: Punch Time Explosion is a mascot brawler fighting game bringing together several characters from the Cartoon Network Multiverse in one epic battle that plays very similarly to the Super Smash Bros. series. Up to four players (human or CPU controlled) control a character and fight on a multi-tiered 2D stage. Players may use various items that appear randomly to get the fighting edge over their opponent. Additionally, the stage may use set elements in order to take out other players. For example, in the Dexter's Lab Stage players can pull 2 different levers, one setting off a conveyor belt, and the other firing a deadly laser.

When players strike one another, glowing cubes will fall out of them. If players collect enough of these cubes, they will fill up their special meter that, when full, unleashes a powerful "Punch Time Explosion" (the equivalent of a Final Smash in Super Smash Bros. Brawl) attack against their opponents. For example, Ben turns into one of his aliens and launches missiles all over the stage.

In the XL version, fighting characters can team up with certain assist characters (the equivalents of Assist Trophies) and do Synergy attacks. For example, Madame Foster brings a plate of cookies to the arena, Chowder eats them, turning fat, and Madame Foster rolls him around the stage.

Each character has their own special move set that uses different elements from their respective shows. Each has an up, down, and side attack. Most characters have a projectile attack. Captain K'nuckles is the only character who has a disabling attack