Mutant Herd involves protecting a powerhouse from an invasion of mutants. The mutants crawl towards you from multiple burrows located at each corner of the screen. Using laser beams, you need to prevent the mutant herds from destroying your powerhouse.

The game was even more complicated than this, however, as it was possible to enter the burrows and to shut them down. Once a burrow was entered, you started another phase of the game. A queen mutant and her eggs are hiding in each burrow. You must get to the eggs and plant an explosive charge, while avoiding the queen mutant, who can kill you or move your charge away from her eggs. Once you have succeeded in blowing up the eggs, the burrow is sealed. When you return to the powerhouse screen, you will have one less burrow spewing mutants at you.

The game was even more complicated yet, in that, after each burrow is sealed, your lasers get weaker and the next burrow will have more eggs and be more challenging. You will have won the game when you have sealed all the burrows and successfully protected your powerhouse