The sequel to Pokémon Play It!, this game features the same basic gameplay as its predecessor, with the AI-controlled character Julie teaching the player the rules of the Pokémon trading card game. The new Challenge and Advanced Challenge modes allow the player to conduct full duels against Julie using standard 60-card decks, while Build mode gives the player the opportunity to design a custom deck.

Other changes from the original Pokémon Play It! include new cards from the Fossil and Team Rocket expansions, the correction of some bugs and inaccuracies, and a built-in checklist for the player to keep track of their real-world card collection.