This interpretation of the famous giant monster from the Japanese cinematic industry takes form of a fighting game, only instead of the usual brave martial artists the players control horrifying monsters from the traditional Toho lineage: the titular beast itself, Rodan, Anguirus, Ghidorah, and others. The game has two modes: Normal and Vs. The latter is essentially a two-player mode, which allows the players to engage in giant monster battles in a variety of scenarios. Most of the monsters, however, are locked in the Vs. mode before the player has completed the Normal mode.

The Normal mode puts the player in control of Godzilla, who has to go through five stages before reaching the final boss. Each stage has two battles against two different creatures in two different locations, from which the player has to complete only one in order to proceed to the next stage. Depending on the player's performance, points are awarded; in order to be able to compete against different final bosses, the player has to accumulate more points. If the player only has the minimum required points, only one final boss will be available.

The combat system is similar to other fighting games, with various combinations of buttons executing different moves. Naturally, the normal "punch-kick" scheme is modified to suit the monsters' shapes and biological peculiarities. For example, monsters with tails can use tail spin attacks; fire-breathing monsters have a range fire attack, etc. Most of the monsters (including Godzilla) have a move when they hold the opponent and suck its blood.